Watch: Understanding ALS

In this lecture, Dr. Goodenowe explains the biochemistry behind ALS, including the role of peroxisomal failure, plasmalogen depletion, and the downstream effects on neuron integrity and inflammation.

1

Set Your Baseline

We begin by measuring what’s happening inside the body of an individual diagnosed with ALS. 

The BioMetrix™ BioScan comprehensively measures key biochemical systems. 

The BioMetrix™ NeuroMRI technology uses the most advanced 3T MRI instrumentation. Nine proprietary sequence programs are utilized to measure all aspects of human brain structure and function. 

2

Begin Your Restorative Health Journey

The BioNutix™ Nutrition program comprehensively supplies the body with key biochemical intermediates, cofactors, and nutrients. 

Key biochemical systems that require special support in ALS include:

  • Proprietary Plasmalogen precursor supplements
  • Proprietary complex lipid nutrition including human optimized phosphatidylcholine
  • Mitochondrial function and capacity support
  • Inflammation resolving support
  • And more…

A lifestyle plan is developed with you in mind. Every person has unique challenges and opportunities in their personal life. Restoring health is not a quick fix. It is a life-long endeavour. Building and optimizing a plan that you can follow for the rest of your life is critical to a successful and sustainable recovery path.

3

Monitor, Improve, and Perpetuate Your Health

This isn’t a one-time fix — it’s a process of continual improvement.

The Immorta™ self-directed personal research software is a comprehensive system for tracking your health data over time. Designed to support your long-term restorative and preventive health goals, Immorta serves as your personal database. It stores all of your lab results and assessments, while also allowing you to log your diet, exercise, medications, and any other relevant health information.

The Engage™ educational and community interaction software program is designed to help you connect, learn, and grow throughout your health journey.

Engage is your gateway to a broad database of informational content covering a wide range of health and technology topics. It also connects you with a community of individuals facing similar health challenges. We are stronger together — learning from one another, offering support, and finding inspiration through shared experience. If you want to run a 4-minute mile, you train with runners who have done it. Engage is what makes perpetual health perpetually fun and rewarding.

What Our ALS Program Looks Like

Biochemical & Functional Assessments

We begin with objective testing to measure what’s happening inside the body. These tools help us understand how ALS is progressing and which functions are being lost.

Key assessments include:

Blood-Based Biochemical Testing

Our BioMetrix™ BioScan includes targeted blood testing for markers associated with ALS progression:

    • Plasmalogen levels, often severely depleted in ALS
    • D-serine elevation, associated with excitotoxicity
    • Microglial activation, a marker of neuroinflammation
    • Myelin basic protein (MBP), reflecting white matter integrity
    • Other markers related to oxidative stress and lipid metabolism

ALS Functional Rating Scale (ALSFRS)

A clinical tool used to monitor ALS progression over time. It tracks changes in core daily functions such as:

    • Speech, swallowing, salivation, and breathing
    • Handwriting and fine motor skills
    • Walking, climbing stairs, and mobility in bed
    • Sleep disturbances and need for breathing support

In conventional care, ALSFRS typically declines by ~1 point per month. In our program, we’ve observed measurable increases in ALSFRS scores over the first few months — a sign of functional improvement.

These assessments help us map how the ALS is affecting the body and allow us to track improvements over time, so we’re not just hoping something’s working. We’re measuring it.

MRI Brain Imaging

Advanced MRI imaging is used to visualize and quantify the structural damage to gray matter (cortical thinning) and white matter (myelin depletion) in the brains of our ALS clients. These assessments serve as critical tools to understand the disease's predictable progression and to monitor the efficacy of the restorative health program by showing improvements in these previously damaged areas.

Restoration & Optimization of Biochemical and Physiological Health

Our program addresses key biochemical deficiencies - especially plasmalogen depletion - through a personalized, assessment-driven nutritional strategy. These interventions are designed to support overall function, slow progression, and restore critical systems impacted by ALS.

Each client receives a custom biochemical restoration plan that may include:

  • NeuroRestore Supplement Protocol, featuring:
    • Omega-3 (gray matter) and omega-9 (white matter) plasmalogen precursor
    • NAC, niacin, phosphatidylcholine, CoQ10, and other essential cofactors
  • Dietary strategies and clean hydration (reverse osmosis, molecular hydrogen water)

To support circulation, muscle tone, recovery, and function, we incorporate a range of specialized tools and services.

These may include:

  • CVAC (Cyclic Variations in Adaptive Conditioning) to stimulate cellular efficiency
  • KAATSU Bands to support muscle activation and vascular growth
  • BEMER Therapy to enhance microcirculation
  • Movement and physical support therapies focused on mobility, posture, and independence
  • Cognitive rehab and personal development sessions to support mental resilience

Personalized Health Management Hub

Our secure, personalized digital platform, Immorta, is your central hub for everything related to your health journey through Perpetual Health. It’s where all of your assessments, protocols, reporting and health data are securely stored - in one place, always accessible.

Clients use Immorta to:

  • View their lab results and reports, and protocol details
  • Track changes over time in key biomarkers and functional metrics
  • Access their full health history, including past assessments and updates
  • Share results and progress with their Navigation Team, practitioners, or care partners
  • Stay connected and informed at every stage of their program

Immorta helps you stay organized, informed, and in control of your health data - all in one place.

Education & Community

Our private online platform, ENGAGE, is your learning and support space within the Perpetual Health program - designed to help you build understanding, connect with others, and take action based on the latest science.

It brings together individuals and caregivers navigating neurological conditions, complex health challenges, or longevity concerns - including ALS, dementia, Parkinson’s, MS, autism, and rare diseases - into a shared space for learning, reflection, and support.

Through ENGAGE, clients can:

  • Explore key scientific insights behind the program, including the role of plasmalogens in brain and body function
  • Learn at their own pace through clear, easy-to-understand content that grows over time
  • Connect with a broader community of individuals navigating similar health journeys
  • Stay informed with evolving materials shaped by ongoing research and clinical experience

ENGAGE is built to empower. Offering the tools, context, and connection needed to help you take meaningful steps toward long-term restoration.

Navigation Team & Support

Throughout your program, you’ll have access to our Navigation Team - a dedicated support team here to help you stay organized, informed, and connected.

The Navigation Team serves as your main point of contact for:

  • Answering questions about your program
  • Helping you understand what to expect at each stage
  • Coordinating blood draws and report interpretation calls
  • Organizing supplement protocol shipments
  • Providing resources and relevant updates
  • Connecting you to the right person if a deeper question comes up

While they are not medical providers, the Navigation Team plays an important role in making sure your experience is smooth, supported, and never confusing. You can reach out any time you need assistance or clarification.

This is not a replacement for your current care – it’s a new layer of support for those who are ready to take action.

A detailed look at Perpetual Health Tools and Technologies

Below is an overview of some of the assessments, interventions, and supports we utilize to track, guide, and personalize each participant’s care.

Tools and Technologies
HEALTH ASSESSMENTS
BioMetrix™ BioScan ℹ️✔️
BioMetrix™ NeuroMRI ℹ️✔️
InBody 770 Advanced Body Composition Machine ℹ️✔️
Livenpace Dynamic 24-Hour 12-Lead ECG Holter ℹ️✔️
Spirometry – Pulmonary Function Test ℹ️✔️
Balance Tracking System ℹ️✔️
Hearing Test ℹ️✔️
Eye Exam ℹ️✔️
Purdue Pegboard Test ℹ️✔️
Functional Reach Test (FRT) ℹ️✔️
Lafayette Hand Dynamometer ℹ️✔️
Mobility Testing ℹ️✔️
Vital Signs ℹ️✔️
Quality of Life Questionnaire ℹ️✔️
ADAS Cognitive Assessment ℹ️✔️
BIOCHEMICAL RESTORATION
BioNutrix™ NeuroRestore Supplement Protocol ℹ️✔️
Reverse Osmosis Water ℹ️✔️
Molecular Hydrogen Water ℹ️✔️
PHYSIOLOGICAL RESTORATION
Kaatsu Bands ℹ️✔️
BEMER Pads ℹ️✔️
VitalStim Therapy ℹ️✔️
TheraGrip ℹ️✔️
Cyclic Variations in Adaptive Conditioning (CVAC) ℹ️✔️
Functional Movement Sessions ℹ️✔️
PSYCHOLOGICAL RESTORATION
ENGAGE Community & Education Platform ℹ️✔️
Mental Health Sessions ℹ️✔️
Community Gatherings & Outings ℹ️✔️
Navigational & Support Team ℹ️✔️

Reduced Fatigue

Improvement in Speech

Improvement in Breathing

Increased Range of Motion

Increased Strength

Increased Confidence & Resolve

Please note: Every individual’s experience is unique. While these improvements have been observed in some clients, results vary and cannot be guaranteed.

FAQ

What makes your approach different?

We combine personalized biochemical data, advanced imaging, and functional assessments with real-world strategies and a strong focus on education. Clients are active participants in a guided, measurable process of restoration.

Is this program right for me or my loved one?

Our programs are designed for individuals seeking a proactive, science-based path to improve quality of life and function—whether newly diagnosed or looking to maintain independence. We work with caregivers and support systems as well.

Do I need to travel to participate?

We offer a 4-month flagship program that includes 3 months on-site in Moose Jaw, Saskatchewan, plus 1 month of remote support. We also offer a condensed 1-month on-site program and 1 month remote options.

How do I get started?

You can begin by exploring programs by condition, or book a call with our team to learn more.

Is the ALS program available remotely?

Yes. Our ALS program can be done remotely. It is available when mobility or location is a challenge.

Our testing kits can be shipped to your home, consultations are held via video call, and all support materials are provided digitally. If advanced imaging (NeuroMRI) is recommended, we’ll help coordinate it through a location near you.